P-40: Melatonin Could Improve The Sperm Quality, Level of Antioxidant Enzymes and Lipid Peroxidation of Testis after The Combination of Swimming Exercise and Supraphysiological Dose of Nandrolone Decanoate in Rats

Background: This study investigates the effects of melatonin on the sperm quality, the level of antioxidant enzymes (TAC) and malondialdehyde (MDA) after the combination of swimming exercise and nandrolone decanoate (DECA). Materials and Methods: Two groups of male Wistar rats were treated for eight weeks as follows; group A consist of: CO (control), Sham, N (DECA), S (swimming) and NS (DECA plus swimming); and group B: Sham M (sham melatonin), M (melatonin), MN (melatonin plus DECA), MS (melatonin plus swimming), MNS (melatonin, DECA plus swimming). Results: The motility of sperm was significantly improved in melatonin groups in comparison to N, S and NS groups (p ≤0.05). The level of MDA of testes significantly increased and the level of TAC decreased in N and NS groups in compare with the control group. Sperm motility was inversely correlated with MDA and directly to TAC levels, respectively (p ≤0.05). The left testes weight was decreased in N, NS and MNS groups and the right testes weight was decreased in N,S,NS,MS and MNS groups in compare with control group. Conclusion: This study concluded that melatonin probably could improve the sperm motility and sex organs weight after the combination of DECA and exercise which results from increasing the level of TAC.